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Table 5 Clinical characteristics of patients in AA group and non-AA group

From: De novo upper tract urothelial carcinoma after renal transplantation: a single-center experience in China

Variable

AA group

non-AA group

p-value

Number of patients, n (%)

81 (76.4%)

25 (23.6%)

 

Age at transplantation, years

48 (45–52)

51 (36–55)

0.985

Age at UTUC, years

56 (51–60)

59 (44–68)

0.350

Time to UTUC, months

89 (47.5–134)

125 (53–177.5)

0.132

Male/female ratio

10/71

7/18

0.120

Smoking history, n (%)

3 (3.7%)

1 (4.0%)

0.946

Symptoms, n (%)

   

Ipsilateral hydronephrosis

69 (85.2%)

21 (84.0%)

1.00

Hematuria

67 (82.7%)

20 (80%)

0.991

Tumor staging, n (%)

  

0.135

T ≥ 2

38 (46.9%)

16 (64.0%)

 

T < 2

43 (53.1%)

9 (36.0%)

 

Lymph node staging, n (%)

  

0.154

 N + 

2 (2.5%)

3 (12.0%)

 

 N0

79 (97.5%)

22 (88.0%)

 

Tumor grade, n (%)

  

0.142

 G3

35 (43.2%)

15 (60.0%)

 

 G1/G2

46 (56.8%)

10 (40.0%)

 

Multifocality, n (%)

56 (69.1%)

11 (44.0%)

0.023

Location, n (%)

  

0.104

 Renal pelvis only

19 (23.5%)

5 (20.0%)

 

 Ureter only

21 (25.9%)

12 (48.0%)

 

 Pelvis and ureter

41 (50.6%)

8 (32.0%)

 

Concomitant BC, n (%)

27 (33.3%)

6 (24.0%)

0.378

Contralateral recurrence, n (%)*

33 (45.8%)

2 (9.1%)

0.002

Bladder recurrence, n (%)#

19 (35.2%)

5 (26.3%)

0.479

  1. *Totally 94 patients were included for analysis of contralateral recurrence, except 7 patients with synchronous bilateral UTUC, 1 patient with contralateral resection due to renal tuberculosis, and 4 patients with contralateral resection before development of UTUC; #: Totally 73 patients were included for analysis of bladder recurrence, except 33 patients with initially concurrent BC
  2. AA Aristolochic acid, UTUC Upper tract urothelial carcinoma, BC Bladder cancer