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Table 1 Factors that lead to stone formation

From: Case report: disease mechanisms and medical management of calcium nephrolithiasis in rheumatologic diseases

Properties that lead to stone formation

Low urine volume (leads to increased concentration of available solutes)

Excess excretion of solutes (calcium, oxalate, uric acid)

Lack of crystal forming inhibitors (citrate, magnesium)

Urine pH changes (Alkaline leads to calcium phosphate supersaturation, Acidic leads to calcium oxalate and uric acid supersaturation)