Fig. 1

Chest and abdominal CT scan. Abnormal findings are indicated by arrowheads. a 18 mm mass found in the right atrium. b Tumor thrombus extending into the renal vein. The right kidney represents a normal and healthy control. c Heterogeneously enhanced left renal tumor. Para-aortic lymphadenopathy is also observed. d–f Multiple small lung nodules suspected of metastases. g, h Multiple bone metastases were observed after the second administration of ipilimumab and nivolumab. i Left renal vein tumor thrombus almost disappears following immunotherapy. j Left renal tumor and para-aortic lymphadenopathy remain reduced with continued immunotherapy