Fig. 2
From: Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy
Pathological image of the specimens of right atrial mass, renal biopsy and left nephrectomy. a A microscopic examination of the atrial tumor shows metastatic carcinoma consisting of large atypical cells. b A microscopic examination of the needle biopsy of the left renal mass shows tumor tissue with high atypia and partial papillary growth. c Gross appearance of the nephrectomy specimen showing necrotic tumor infiltrating the renal parenchyma continuous with papillary tumors present in the renal pelvis. d Low-power images of hematoxylin and eosin staining showing both sarcomatoid and conventional UC components. The sarcomatoid component is composed of eosinophilic spindle-shaped cells. Immunostaining revealed that the sarcomatoid component is positive for CD10 (e), partially weakly positive for GATA-3 (f), and negative for p63 (g) and CK AE1/AE3 (h). PD-L1 is strongly expressed only in the sarcomatoid component (i) and not in the conventional UC component (j). The scale bar indicates 200 μm