Table 1 Inclusion criteria
nmCRPC | mCRPC | mCNPC patients |
|---|---|---|
Consecutive increases in PSA levels, three times with a minimum one-week interval with the last PSA > 2 ng/mL while minimal initial PSA level of ≥ 1 ng/mL or last PSA level of > 2 ng/mL during first-line medical castration | Consecutive increases in PSA levels, three times with a minimum one-week interval with the last PSA level of > 2 ng/mL while minimal initial PSA level of ≥ 1 ng/mL, or during first-line medical castration with the last PSA level of > 2 ng/mL | Had a confirmed diagnosis of metastatic cancer on or after the confirmed diagnosis of the PC |
Had no record of metastatic cancer on or before the index date | Any record of metastatic cancer on or before the index date | Had any record of first-line surgical or medical castration on or after the diagnosis of prostate cancer and metastasis diagnosis (i.e. neither medical nor surgical castrations before the diagnosis of metastasis) |