Table 3 Attrition
Overall population | ||
|---|---|---|
Patients excluded N (%) | Patients remaining N (%) | |
Inclusion criteria | ||
1. Diagnosis of prostate cancer without a suspicious flag | 0 (0.0%) | 386,484 (100.0%) |
2. Having at least one surgical or medical ADT during the study period | 232,310 (60.1%) | 154,174 (39.9%) |
Exclusion criteria | ||
1. Not having a PSA measurement during the study period | 138,837 (87.9%) | 15,337 (12.1%) |
Cohort (nmCRPC) | ||
Inclusion criteria | ||
1. Consecutive increases in PSA levels, 3 times with at least one-week interval with the last PSA > 2 ng/mL while minimal staring PSA level of ≥ 1 ng/mL, or during first-line medical castration with the last PSA > 2 ng/mL | 10,749 (70.0%) | 4588 (30.0%) |
2. Having any record of the first-line surgical or medical castration on or before the index date | 528 (12.9%) | 4060 (87.1%) |
3. Having no record of metastatic cancer on or before index date | 1506 (40.0%) | 2554 (60.0%) |
Exclusion criteria | ||
1. Diagnosis of any cancer other than prostate cancer on or before first confirmed diagnosis of prostate cancer | 256 (9.5%) | 2298 (90.5%) |
2. Having less than 90 days of washout before the index date | 515 (22.4%) | 1783 (77.6%) |
Cohort (mCRPC) | ||
Inclusion criteria | ||
1. Consecutive increases in PSA levels, 3 times with at least one-week interval with the last PSA > 2 ng/mL while minimal initial PSA level of ≥ 1 ng/mL, or during first-line medical castration with the last PSA > 2 ng/mL | 10,749 (70.0%) | 4588 (30.0%) |
2. Having any record of the first-line surgical or medical castration on or before the index date | 528 (12.9%) | 4060 (87.1%) |
3. Any record of metastatic cancer on or before the index date | 2554 (60.0%) | 1506 (40.0%) |
Exclusion criteria | ||
1. Diagnosis of any cancer other than prostate cancer on or before the first confirmed diagnosis of prostate cancer | 793 (47.0%) | 713 (53.0%) |
2. Having less than 90 days of washout before the index date | 83 (11.6%) | 630 (88.4%) |
Cohort (mCNPC) | ||
Inclusion criteria | ||
1. Diagnosis of metastatic cancer on or after the diagnosis of the prostate cancer | 11,617 (76.8%) | 3720 (23.2%) |
2. Any record of the first-line surgical or medical castration on or after the diagnosis of the prostate cancer and the diagnosis of the metastasis | 1599 (39.6%) | 2121 (60.4%) |
Exclusion criteria | ||
1. Diagnosis of any cancer other than prostate cancer on or before the first confirmed diagnosis of prostate cancer | 143 (8.7%) | 1978 (91.3%) |
2. Having less than 90 days of washout before the index date | 1524 (77.0%) | 454 (23.0%) |