Table 2 Correlation analysis between Nuf2 and biomarker genes of immune cells in ccRCC
From: NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma
Cell type | Gene markers | GEPIA | Timer | ||
|---|---|---|---|---|---|
Cor | P-Value | Cor | P-Value | ||
CD8 + T cell | CD8A | 0.21 | 9.2E − 07 | 0.381 | 7.90E-20 |
| Â | CD8B | 0.16 | 3.7E-04 | 0.327 | 9.18E-15 |
T cell (general) | CD3D | 0.18 | 5.5E − 05 | 0.373 | 4.98E-19 |
|  | CD3E | 0.18 | 2.8E − 05 | 0.363 | 4.60E-18 |
|  | CD2 | 0.19 | 8.9E − 06 | 0.414 | 1.97E-23 |
B cell | CD19 | 0.068 | 1.2E-01 | 0.269 | 2.78E-10 |
| Â | CD79A | 0.025 | 5.7E-01 | 0.198 | 4.09E-06 |
Monocyte | CD86 | 0.17 | 7.2E-05 | 0.365 | 3.00E-18 |
| Â | CD115 | 0.11 | 9.4E-03 | 0.278 | 6.68E-11 |
TAM | CCL2 | -0.08 | 6.8E-02 | 0.018 | 6.75E-01 |
| Â | CD68 | 0.038 | 3.8E-01 | 0.272 | 1.78E-10 |
| Â | IL10 | 0.095 | 2.9E-02 | 0.319 | 5.91E-15 |
M1 Macrophage | NOS2 | −0.033 | 4.5E-01 | 0.041 | 3.48E-01 |
| Â | IRF5 | 0.072 | 1.0E-01 | 0.311 | 1.89E-13 |
| Â | PTGS2 | 0.02 | 6.4E-01 | 0.116 | 7.38E-03 |
M2 Macrophage | CD163 | 0.22 | 6.5E − 07 | 0.253 | 3.12E-09 |
|  | VSIG4 | 0.24 | 2.4E − 08 | 0.294 | 4.58E-12 |
| Â | MS4A4A | 0.16 | 3.7E-04 | 0.27 | 2.42E-10 |
Neutrophils | CD66b | 0.017 | 7.0E-01 | 0.025 | 5.71E-01 |
|  | CD11b | 0.013 | 7.7E-01 | 0.125 | 4.02E + 00 |
| Â | CCR7 | 0.024 | 5.8E-01 | 0.254 | 2.65E-09 |
Natural killer cell | KIR2DL1 | -0.069 | 1.1E-01 | 0.026 | 5.46E-01 |
| Â | KIR2DL3 | -0.034 | 4.4E-01 | 0.062 | 1.50E-01 |
| Â | KIR2DL4 | 0.13 | 2.7E-03 | 0.188 | 1.19E-05 |
| Â | KIR3DL2 | -0.05 | 2.6E-01 | 0.067 | 1.24E-01 |
| Â | KIR3DL3 | 0.022 | 6.2E-01 | 0.041 | 3.14E-01 |
| Â | KIR2DS4 | -0.059 | 1.8E-01 | -0.034 | 4.37E-01 |
Dendritic cell | HLA-DPB1 | 0.035 | 4.3E-01 | 0.251 | 4.19E-09 |
| Â | HLA-DQB1 | 0.035 | 4.3E-01 | 0.131 | 2.40E-03 |
| Â | HLA-DRA | 0.066 | 1.3E-01 | 0.288 | 1.14E-11 |
| Â | HLA-DPA1 | 0.04 | 3.6E-01 | 0.287 | 1.55E-11 |
| Â | CD11c | 0.12 | 5.5E-03 | 0.331 | 4.25E-15 |
Th1 | T-bet | 0.1 | 2.2E-02 | 0.262 | 8.43E-10 |
| Â | STAT4 | 0.11 | 9.3E-03 | 0.404 | 2.68E-22 |
|  | STAT1 | 0.28 | 9.5E − 11 | 0.427 | 3.30E-26 |
|  | IFN-γ | 0.4 | 0.0E + 00 | 0.465 | 6.87E-30 |
| Â | TNF-a | 0.044 | 3.2E-01 | 0.234 | 4.81E-08 |
Th2 | GATA3 | 0.2 | 2.8E − 06 | 0.139 | 1.26E-03 |
| Â | STAT6 | -0.046 | 3.0E-01 | 0.112 | 9.84E-03 |
| Â | STAT5A | 0.086 | 4.8E-02 | 0.241 | 1.73E-08 |
| Â | IL13 | -0.029 | 5.0E-01 | -0.014 | 7.53E-01 |
Tfh | BCL6 | 0.021 | 6.4E-01 | 0.13 | 2.62E-03 |
|  | IL21 | 0.24 | 1.9E − 08 | 0.205 | 1.74E-06 |
Th17 | STAT3 | 0.025 | 5.7E-01 | 0.121 | 5.31E-03 |
| Â | IL17A | 0.0055 | 9.0E-01 | 0.029 | 5.09E-01 |
Treg | FOXP3 | 0.18 | 2.3E − 05 | 0.398 | 1.11E-21 |
| Â | CCR8 | 0.14 | 1.2E-03 | 0.384 | 3.80E-20 |
| Â | STAT5B | -0.12 | 6.5E-03 | -0.062 | 1.54E-01 |
|  | TGFB1 | 0.22 | 5.5E − 07 | 0.227 | 1.15E-07 |
T cell exhaustion | PD-1 | 0.27 | 2.2E-10 | 0.358 | 1.53E-17 |
|  | CTLA4 | 0.33 | 2.3E − 14 | 0.419 | 3.94E-24 |
|  | LAG3 | 0.3 | 1.5E − 12 | 0.44 | 1.32E-26 |
| Â | TIM-3 | -0.037 | 4.0E-01 | 0.134 | 1.99E-03 |
|  | GZMB | 0.41 | 0.0E + 00 | 0.293 | 5.60E-12 |
|  | TOX | 0.19 | 1.4E − 05 | 0.446 | 4.16E-21 |
|  | TIGIT | 0.3 | 2.1E − 12 | 0.446 | 2.24E-27 |