Fig. 4

Microscopic slides demonstrate solid sheets of atypical cytotrophoblast and syncytiotrophoblast with infiltrative and destructive pattern and high mitotic activity in a background of necrosis and hemorrhage. (a) Tumoral cells exhibiting pleomorphism, extensive hemorrhage and blood-filled cystic spaces (b) Extensive involvement of mucosa with tumoral cells with lakes of hemorrhage separating tumoral cells (c) Intestinal mucosa is infiltrated by anaplastic tumoral cells replacing the bowel muscular wall extending up to muscularis mucosa. Both cytotrophoblast and multinucleated syncytiotrophoblast are depicted in the field. (d) Sheets of highly anaplastic cells with a mitosis at the center of the field