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Table 3 Characteristics associated with overall, bladder cancer-specific, and recurrence-free survival, by postoperative medication

From: Chronic prednisone, metformin, and nonsteroidal anti-inflammatory drug use and clinical outcome in a cohort of bladder cancer patients undergoing radical cystectomy in Québec, Canada

 

Overall survival

Bladder cancer-specific survival

Recurrence-free survival

Univariable

Multivariable

Univariable

Multivariable

Univariable

Multivariable

Postoperative medication use

      

- Statins

0.90

(0.80–1.01)

0.76

(0.63–0.91)

0.79

(0.69–0.91)

0.65

(0.53–0.81)

0.82

(0.72–0.93)

0.69

(0.56–0.84)

- NSAIDs

1.14

(1.00-1.30)

1.34

(1.11–1.61)

1.08

(0.92–1.27)

1.46

(1.18–1.82)

1.12

(0.96–1.30)

1.47

(1.20–1.80)

   - Aspirin

1.16

(1.03–1.30)

1.16

(0.96–1.41)

0.98

(0.85–1.14)

1.18

(0.94–1.48)

0.91

(0.80–1.04)

1.05

(0.85–1.30)

   - Other NSAIDs

1.13

(0.99–1.29)

1.25

(1.05–1.49)

1.24

(1.06–1.46)

1.49

(1.22–1.82)

1.40

(1.21–1.63)

1.55

(1.29–1.87)

- Metformin

1.16

(0.98–1.38)

1.18

(0.93–1.50)

1.19

(0.97–1.46)

1.32

(0.99–1.75)

1.25

(1.04–1.51)

1.31

(1.01–1.70)

- Prednisone

1.07

(0.92–1.23)

0.85

(0.70–1.03)

0.93

(0.77–1.11)

0.87

(0.69–1.09)

0.96

(0.81–1.13)

0.87

(0.71–1.08)

  1. Uni- and multivariable Cox proportional-hazards regression models were used to calculate hazard ratios and their respective 95% confidence intervals. In the multivariable analyses, we adjusted for age, sex, region of residence, Charlson’s comorbidity index, year of surgery, distance to the hospital, hospital type, hospital and surgeon RC volume, type of bladder diversion, neoadjuvant chemotherapy use, and postoperative medication use (mutual adjustment for statin, NSAID, metformin, and prednisone use). Hazard ratios with a p-value of less than 0.050 are marked in bold
  2. NSAID, nonsteroidal anti-inflammatory drugs; RC, radical cystectomy