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Table 3 Univariate and multivariate analysis of Overall Survival (OS).

From: Factors affecting survival and prognosis in surgically treated patients with spinal metastases arising from renal cell carcinoma

Factors

Univariate

Multivariate

Cases

Events

Χ2

p-value

B

HR

95% CI

p-value

Sex

M

38

26

2.332

0.127

NI

F

11

7

Age of RCC

≤ 55

25

17

1.527

0.217

NI

> 55

24

16

Age of spinal metastases

≤ 58

26

17

1.523

0.217

NI

> 58

23

16

Metabolism syndrome(yes/no)

Yes

31

23

0.94

0.759

NI

No

18

10

Spinal metastases combined with visceral metastasis (yes/no)

Yes

32

18

5.914

0.015

0.366

1.442

0.41–5.702

0.569

No

17

15

NLR

≤ 7.78

38

26

0.460

0.497

NI

> 7.78

11

7

PLR

≤ 282.29

42

27

3.563

0.059

NI

> 282.29

7

6

HALP

≤ 20.67

16

9

5.063

0.024

0.631

1.88

0.695–5.086

0.214

> 20.67

33

24

Pre-op Frankel score

(A–C/D,E)

A–C

30

22

9.776

0.002

0.453

1.573

0.250–9.900

0.629

D,E

19

11

AJCC RCC Stage

1,2

17

11

5.177

0.023

-0.101

0.904

0.250–3.269

0.877

3,4

32

22

WHO/ISUP Grade

2

16

10

15.477

< 0.001

1.025

2.787

1.595–4.870

< 0.001

3

21

15

4

12

8

Pre-op KPS Score (≤ 60/>60)

≤ 60

34

24

8.608

0.003

-0.175

0.84

0.120–5.880

0.86

> 60

15

9

ECOG Score (1–2/3–4)

0–2

18

11

11.566

0.001

-1.188

0.305

0.113–0.825

0.019

3–5

31

22

multiple spinal metastases

YES

13

10

28.976

< 0.001

-2.563

0.077

0.019–0.319

< 0.001

NO

36

23

Strategy of spinal surgery(TES surgery/separation surgery)

TES surgery

33

24

19.027

< 0.001

0.883

2.301

0.518–10.227

0.274

Separation surgery

16

9

  1. Abbreviations: NLR,neutrophil-to-lymphocyte ratio; PLR,platelet-to-lymphocyte ratio; HALP,hemoglobin and albumin levels and lymphocyte and platelet counts; AJCC,American Joint Committee on Cancer; WHO,World Health Organization; ISUP,International Society of Urology and Pathology; Pre-op ,preoperative; KPS,Karnofsky Performance Status; ECOG,Eastern Cooperative Oncology Group; TES,total en-bloc spondylectomy;NI,not included in the multivariate analysis; NS,not significant in the multivariate analysis.