Fig. 5

GPR12 overexpression reversed the effects of miR-105-5p on BC cell growth and metastasis. A mRNA and B protein levels of GPR12 were measured under the treatment of miR-105-5p mimic or inhibitor. C Cell viability, D and E migration and F invasion of EJ and T24 cells were determined after transfection with miR-105-5p or GPR12. Experiments were conducted thrice for each approach. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001; ^****P < 0.0001. BC, bladder cancer