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Fig. 3 | BMC Urology

Fig. 3

From: The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation

Fig. 3

PFK-1 suppressed the histone lactylation of BC cells and ZEB1 transcriptional activity. After sh-PFK-1 transfection and LA treatment, (A) the expression of pan-kla and H3K18la was measured by western blot. (B, C) ChIP assay showed that PFK-1 knockdown inhibited the binding of H3K18 with the promoter of ZEB1. (D, E) Luciferase assay further indicated that PFK-1 knockdown suppressed the transcription activity of ZEB1. Sh-PFK-1 transfection decreased the mRNA (F-G) and protein (H) level of ZEB1ZEB1 mRNA expression in UM-UC-1 and RT112 cell lines

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BMC Urology

ISSN: 1471-2490

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