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Fig. 4 | BMC Urology

Fig. 4

From: The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation

Fig. 4

ZEB1 overexpression reversed the effects of PFK-1 silencing on BC progression. (A) After ZEB1 overexpressed vector transfection, the mRNA levels of ZEB1 were increased in UM-UC-1 and RT112 cells. The UM-UC-1 and RT112 cells were transfected with sh-PFK-1 and ZEB1 overexpressed vector. (B) CCK-8 assay showed ZEB1 overexpression increased the cell viability of UM-UC-1 and RT112 cells. (C-D) Colony formation assay showed ZEB1 overexpression increased cell growth of UM-UC-1 and RT112 cells. Transwell assay showed ZEB1 overexpression increased the migration (E-F) and invasion (G-H) of UM-UC-1 and RT112 cells. After ZEB1 overexpression, relative glucose consumption (I), lactate production (J) and ECAR (K-L) were increased in UM-UC-1 and RT112 cells

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BMC Urology

ISSN: 1471-2490

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