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Partial Segmental Thrombosis of the Corpus Cavernosum (PSTCC) diagnosed by contrast-enhanced ultrasound: a case report
BMC Urology volume 14, Article number: 100 (2014)
Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare disease predominantly occurring in young men. Cardinal symptoms are pain and perineal swelling. Although several risk factors are described in the literature, the exact etiology of penile thrombosis remains unclear in most cases. MRI or ultrasound (US) is usually used for diagnosing this condition.
We report a case of penile thrombosis after left-sided varicocele ligature in a young patient. The diagnosis was established using contrast-enhanced ultrasound (CEUS) and was confirmed by contrast-enhanced magnetic resonance imaging (ceMRI). Successful conservative treatment consisted of systemic anticoagulation using low molecular weight heparin and acetylsalicylic acid.
PSTCC is a rare condition in young men and appears with massive pain and perineal swelling. In case of suspected PSTCC utilization of CEUS may be of diagnostic benefit.
Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare disease predominantly occurring in young men . Priapism (prolonged and painful penile erection) must be discerned from actual thrombosis of the corpus cavernosum . PSTCC is characterized by thrombosis that most often is unilateral andlocated in the proximal part of the corpus cavernosum. Cardinal symptoms are massive pain and perineal swelling . The etiology of penile thrombosis remains unclear. Several risk factors are described in the literature [2–6]. In most patients an excellent outcome is achieved with conservative treatment [7, 8].
MRI or ultrasound (US) are usually used for diagnosis . This report describes the use of contrast-enhanced ultrasound (CEUS) for assessment of penile thrombosis.
A 23-year-old male was admitted to our university hospital with severe pain and a history of progressive perineal swelling over a period of two weeks. His medical history was non-contributory except a left-sided varicocele ligature performed six years ago. No sexual trauma, dysuria or urethral discharge was reported by the patient. Excessive bicycle riding, masturbation, marijuana or cocaine consumption as well as recent long distance flights were negated.
Physical examination confirmed the absence of priapism. A firm, fixed and extremely painful mass was palpable at the proximal penis. The complete blood count, electrolytes, coagulation profile, CRP and urine analysis were unremarkable.Gray-scaled ultrasound (Siemens Acuson S2000, Siemens Sector Healthcare, Erlangen, Germany) combined with color Doppler of the penis using a 6 MHz transducer (Siemens 6C1 HD, Siemens Sector Healthcare, Erlangen, Germany) revealed an elongated hypoechogenic mass (Figure 1, arrow) with irregular hyperechogenic internal echoes. Color Doppler ultrasound demonstrated absence of flow within the inhomogeneous mass (Figure 2, arrow).Contrast-enhanced ultrasound (Acuson Sequoia with 4 MHz transducer, Siemens Sector Healthcare, Erlangen, Germany; 1.2 ml SonoVue®, Bracco Imaging, Milano, Italy) revealed a lack of contrast enhancement in the hypoechogenic mass. This was interpreted as segmental thrombosis of the corpus cavernosum (Figure 3, arrow).For confirmation of this diagnosis a MRI study (1.5 T Siemens Avanto, Siemens Sector Healthcare, Erlangen, Germany) of the pelvis was performed. Transversal T2-weighted images of the pelvis showed a hypointense thrombus of the right proximal corpus cavernosum (Figure 4a, white arrow). T1-weighted fat saturated transversal scans after intravenous contrast medium injection (Gadovist®, Bayer HealthCare AG, Leverkusen, Germany) revealed an intermediate signal and a lack of contrast uptake in the right proximal corpus cavernosum (Figure 4b, black arrow) consistent with sub-acute partial segmental thrombosis of the corpus cavernosum.
Conservative treatment was initiated and consisted of anticoagulation with low molecular weight heparin (Enoxaparin 40 mg once daily) and acetylsalicylic acid (100 mg once daily).
Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare urological disease which primarily occurs in young men with a mean age of 30 years (range 18–59 years) . Differential diagnoses include inflammatory processes as well as solid tumors .
PSTCC´s etiology is poorly understood. Although several risk factors have been described, the exact etiology still remains unclear. Recently Ilicki et al.  postulated a two-hit model in which first a transverse membrane, dividing the corpus into a proximal and distal portion, and second a triggering event (microtrauma) is required for the emergence of corpus cavernosum thrombosis. In the presented case no solid membrane as a potentially flow-limiting factor was identified, neither in CEUS nor in MRI. Such membranes may predestinate the emergence of PSTCC but their presence may not be mandatory.
Risk factors for development of PSTCC include haematological abnormalities (sickle cell disease, leukemia, homocysteinemia), abuse of alcohol or drugs (marijuana, cocaine), hypercoagulability associated with malignancy and long distance flights as well as microtrauma after coitus or extended cycling [1–6].
Standard imaging modalities include color coded duplex sonography, MRI and CT imaging. The benefits of contrast enhanced MRI have been demonstrated by several authors [1, 2, 6, 11]. In recent years, CEUS has been found to be a cost- efficient alternative in diagnosis of organ and soft tissue pathologies, especially in patients with contraindications for MRI.
This case report outlines the utility of CEUS as an additional cost-saving diagnostic tool for assessment of PSTCC, especially in patients with contraindications for MRI.
The first cases of PSTCC were described in 1976 . At that time surgical treatment was the method of choice. Nowadays, as in this case, conservative treatment with systemic anticoagulation appears to be an excellent and reliable therapeutic option. Recent literature shows that all patients treated conservatively have maintained erectile function [5, 7, 8, 13]. Surgery is reserved for patients in whom conservative management fails .
PSTCC is a rare condition that predominantly occurs in young men and is accompanied with massive pain and perineal swelling. There are several risk factors described, including abuse of alcohol or drugs, hypercoagulability associated with malignancy and long distance flights as well as microtrauma after coitus or extended bicycle riding. CEUS may be of diagnostic benefit if one suspects PSTCC. Larger studies are warranted to verify this hypothesis. Conservative treatment with systemic anticoagulation has shown excellent results concerning pain relief and erectile dysfunction.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
Partial segmental thrombosis of the corpus cavernosum
Contrast-enhanced magnetic resonance imaging
Ilicki J, Krauss W, Andersson S-O: Partial segmental thrombosis of the corpus cavernosum: a case report and a review of the literature. Urology. 2012, 79: 708-712. 10.1016/j.urology.2011.11.032.
Goeman L, Joniau S, Oyen R, Claes H, Van Poppel H: Idiopathic partial thrombosis of the corpus cavernosum: conservative management is effective and possible. Eur Urol. 2003, 44: 119-23. 10.1016/S0302-2838(03)00217-3.
Blaut S, Schneider M, Zschuppe E, Günl U, Steinbach F: Partial unilateral penile thrombosis of corpus cavernosum due to hyperhomocysteinemia. Case report and references. Urologe A. 2008, 47: 748-52. 10.1007/s00120-008-1650-4.
Schneede P, Schmeller N, Müller-Lisse UG, Reiser MF, Hofstetter AG: Partial priapism. Case report and review of the literature of diagnostic and therapeutic measures. Urologe A. 1999, 38: 179-83. 10.1007/s001200050263.
Lewis JH, Javidan J, Keoleian CM, Shetty SD: Management of partial segmental priapism. Urology. 2001, 57: 169-
Horger DC, Wingo MS, Keane TE: Partial segmental thrombosis of corpus cavernosum: case report and review of world literature. Urology. 2005, 66: 194-
Kimball DA, Yuh WT, Farner RM: MR diagnosis of penile thrombosis. J Comput Assist Tomogr. 1988, 12: 604-7. 10.1097/00004728-198807000-00012.
Thiel R, Kahn T, Vögeli TA: Idiopathic partial thrombosis of the corpus cavernosum. Urol Int. 1998, 60: 178-80. 10.1159/000030246.
Pegios W, Rausch M, Balzer JO, Wolfram M, Bentas W, Jonas D, Vogl TJ: MRI and color-coded duplex sonography: diagnosis of partial priapism. Eur Radiol. 2002, 12: 2532-5. 10.1007/s00330-001-1199-8.
Gentile G, Broccoli A, Brunocilla E, Schiavina R, Borghesi M, Romagnoli D, Bianchi L, Derenzini E, Agostinelli C, Franceschelli A, Colombo F, Zinzani PL: An isolated penile mass in a young adult turned out to be a primary marginal zone lymphoma of the penis. A case report and a review of literature. Anticancer Res. 2013, 33: 2639-42.
Patel RP, Mucksavage P, Ramchandani P, Hanno PM, Malkowicz SB: Idiopathic partial thrombosis of the corpus cavernosum. Urology. 2010, 76: 1373-4. 10.1016/j.urology.2009.12.058.
Hillis RS, Weems WL: Priapism: an unusual presentation. J Urol. 1976, 116: 124-5.
Ptak T, Larsen CR, Beckmann CF, Boyle DE: Idiopathic segmental thrombosis of the corpus cavernosum as a cause of partial priapism. Abdom Imaging. 1994, 19: 564-6. 10.1007/BF00198267.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/14/100/prepub
This publication was funded by the German Research Foundation (DFG) and the University of Würzburg in the funding programme Open Access Publishing.
The authors declare that they have no competing interests.
SS and DK performed CEUS. JPG and BP evaluated MRI. BP mainly coordinated the development of the manuscript. TG and ASK assisted in both imaging modalities and helped to design, coordinate and draft the manuscript. TAB as well as JPG advanced the manuscript by revising it critically for important intellectual content. All authors read and approved the final manuscript.
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Sauer, S., Goltz, J.P., Gassenmaier, T. et al. Partial Segmental Thrombosis of the Corpus Cavernosum (PSTCC) diagnosed by contrast-enhanced ultrasound: a case report. BMC Urol 14, 100 (2014). https://doi.org/10.1186/1471-2490-14-100
- Penile thrombosis
- Corpus cavernosum
- Contrast-enhanced ultrasound