- Research article
- Open Access
- Open Peer Review
Transurethral resection of the prostate in Northern Nigeria, problems and prospects
© Alhasan et al; licensee BioMed Central Ltd. 2008
- Received: 07 January 2008
- Accepted: 06 December 2008
- Published: 06 December 2008
Benign prostatic hyperplasia (BPH) is the commonest disease of the urinary tract afflicting the ageing male and is the commonest neoplastic disease in men aged 50 years and above.
Transurethral prostatectomy (TURP) is the ultimate treatment of choice for benign prostatic hyperplasia (BPH) due mainly to the preference of minimally invasive surgery, long term relief of symptoms and cost effectiveness. It is however not available to the majority of Nigerians in need of prostatic surgery in Public Health Institutions.
The records of patients who underwent prostatectomy in Aminu Kano Teaching Hospital, over the period June 2001 to July 2007 were examined. The bio data of patients and laboratory investigations performed were retrieved.
Five Hundred and forty two patients were operated upon, out of which 40 were excluded due to open prostatectomy (22 patients), bladder neck stenosis (16 patients) or bladder tumour around the trigon (2 patients). The age range of the patients was 47–110 years with a mean of 67.2 years. 289 patients (80.1%) had urethral catheter in situ at presentation and 11 (3%) patients had suprapubic cystostomy of which only 3 (0.85%) had combined urethral stricture and BPH.
Only 131 (26%) had their PSA measured which ranged from 2–100 ng/ml out of which 39(29.8% n = 131) patients had more than 4 ng/ml and cancer of the prostate and 1(0.8%, n = 131) patient had a PSA level of 4 ng/ml and malignant prostate.
Hospital stay was 1–32 days (mean 7.9) and the mean follow up period was 5.6 months (range 0–60) and there were 17.5% complications comprising of urinary tract infection (UTI) 7.2%, Orchitis 2.2%, urinary incontinence 0.6%, atonic bladder 1%, erectile dysfunction 0.6%, cerebrovascular accident 0.4%, myocardial infarction 0.4%, deep vein thrombosis 0.4% and disseminated intravascular coagulopathy (DIC) 0.6% and 1.2% mortality. The cost of treatment inclusive of pre-admission investigations was US$ 615.00 (range US$ 300–1,300)
Despite advances in minimally invasive therapy for LUTH/BPH, TURP is the optimum treatment of choice for the ageing male of sub-Saharan Africa. It is however not available to the majority of patients in this region due to poor health allocation and inadequate facilities and training.
- Prostate Specific Antigen
- Benign Prostatic Hyperplasia
- Digital Rectal Examination
- Urethral Stricture
- Public Health Institution
Benign prostatic hyperplasia (BPH) is the commonest disease of the urinary tract afflicting the ageing male and is the commonest tumour in men over the age of 50 years. Clinically, BPH has been reported to occur in 8% of men at the age of 40 years rising to 50% and 90% by the ages of 60 and 80 years respectively . Although reliable data on the true incidence of prostatic diseases in Northern Nigeria is lacking, patients with BPH form the bulk of urology workload in our centre.
Transurethral resection of the prostate (TURP) is the ultimate treatment of choice of BPH, due mainly to the preference of minimally invasive surgery, long term relief of symptoms and cost effectiveness. It is however not available to the majority of Nigerian patients in need of prostatic surgery in public health institutions, while the high cost in private hospitals is generally prohibitive.
This paper reviews our experience with TURP in Aminu Kano Teaching Hospital, Nigeria and examines the prospects of availing the same in other public hospitals despite limited facilities.
The records of patients who underwent prostatectomy in Aminu Kano Teaching Hospital, over the period June 2001 to July 2007 were retrieved and examined. The bio data of patients, records of pre-operative biochemistry, haematological and microbiological investigations performed were also retrieved. Mode of clinical presentation, presence of co-morbidity and its treatment outcome, recorded clinical findings particularly digital rectal examination of the prostate, as well as intra- and post-operative complications and histology of resected prostate chips were also extracted and noted from the patients' case notes and Pathology Department Register respectively.
Informed consents were routinely obtained from all the patients indicating that data recorded in their files could be used for research purposes. The ethical approval was given to all retrospective studies due to its being a form of audit.
Transurethral procedures were carried out by 2 Urological surgeons. Distilled water at a height of 1 metre from the bladder (exerting a pressure head of 98 cmH2O) was used as irrigation fluid and one set of size 27 FG Olympus continuous flow working sheath with 5° telescopes were used for resection of all the prostates.
All procedures were abandoned once a capsular perforation was made and 15 (3%) of such cases were identified.
Excluded were patients who had open prostatectomy and transurethral bladder neck incisions. SPSS 12.0 was used for statistical analysis of extracted data.
A total of 542 patients had prostatectomy out of which 40 were excluded due to open prostatectomy (22 cases), bladder neck stenosis (16 patients) or bladder tumour around the trigon (2 patients). Five hundred and two (502) cases were therefore available for analysis.
Age distribution (years)
Two hundred and eighty nine patients (80.1%) had a urethral catheter in situ at presentation, and 11 (3%) patients had suprapubic catheter (SPC) out of which only 3 (0.85%) had combined urethral stricture and BPH, the others had high riding prostate. Seven patients (1.4%) were identified to have had chronic urinary retention of which 3 (0.6%) never recovered detrusor function and remained with urethral catheter more than a year post-operatively.
Significant co-morbidity was found in 147 (29.3%) patients in the form of cardiovascular disease (137 [27.3%] patients), chronic obstructive airway disease (5 [0.99%] patients) and chronic renal failure (5 [0.99%] patients).
Digital rectal examination revealed benign enlarged prostates in 490(97.6%) patients and 12 (2.4%) patients had suspicious prostate carcinoma, confirmed on biopsy.
The pre-operative Haemoglobin (Hb) of patients was 5–17 g/dl (mean 12.7 ± 2.2 SD) and 154(30.7%) patients with Hb ≤ 10 were transfused pre-operatively. The post operative transfusion rate for all groups was 0.8%.
Medical treatment in the form of Prazocin 4–8 mg (5 patients, 1%) or alfuzocin 10 mg(8 patients, 1.6%) nocte were given to only 13 patients(2.6%) and of this 3 patients(0.6%) in Prazocin group opted for TURP due to intolerable postural hypotension while remaining 2 patients and those in alfuzocin group(totalling 2%) opted for TURP due to cost consideration long term.
Only 71 patients (14%) had IPSS scored in their files, of which 18 patients (3.6%) had a mean IPPS of 14 ± 3.81 SD and 53 patients (10.6%) had IPSS of 24 ± 7.71 SD. Fourteen patients were not scored for IPSS.
Majority of patients (92%) were operated upon under spinal sub-arachnoid block while 6.7% were done under 'saddle' block, using 3 mls of 0.5% bupivacain and 5 patients (1.3%) had general anaesthesia either as conversion (2 patients) or due to sub-arachnoid blockade contra-indications (3 patients).
The amount of prostate chips resected weighed between 3–146 gm (mean 59.8 gm, ± 27.8 SD) over an operation period of 20–120 minutes (mean 64.1 minutes). There was no documented TUR syndrome.
Urethral catheters were removed in 0–30 days (mean 3.8, ± 4.6 SD) but 10 patients (2%) needed re-catheterization, with successful trial without catheter in 7 patients (1.4%) after 2 weeks. Persistent irritative symptoms were recorded in 2 patients (0.4%) who did not improve on medical therapy at one year follow up. Re-operation was performed in 5 patients 2 years after initial operation due to intractable haematuria (2 patients, 0.4%), recurrent adenoma 3 patients (0.6%). All patients had residual urine measured with a urethral catheter before discharge. Satisfactory outcome was recorded in the immediate post-operative period in 483 patients (96.2%).
There were 6 peri-operative deaths (1.2%) in the age groups 56–60 years (DVT/PE/DIC) and 71–75 years (MI). The 2 myocardial infarctions occurred intra-operatively from hypotensive episodes and 3 patients (0.8%) had chronic renal failure due to obstructive uropathy not resolved by TURP.
Hospital stay was 1–32 days (mean 7.9 ± 5.2 SD) and the follow up period was 0–60 months, (mean 5.6 ± 8.3 SD).
The average cost of treatment inclusive of pre-admission work-up investigations was US$300–1,300, (mean US$617.00 ± 231 SD).
Urinary microbial isolates in patients with catheter pre-op.
The highest incidence of LUTS/BPH was found in the age group 56–70 years accounting for a total of 62% of the patients operated in this study. This correlates similar figure reported by Garraway et al of 66% [3, 4].
Co-morbidity is both a strong predictor of length of stay and excess risk of death peri-operatively. Co-morbidities of 29.3% in this study compares favourably to 25% for open prostatectomy in Sicilian-Calabrian region of Italy which may suggest similar standards of healthcare in the 2 regions .
Water was used as irrigation fluid during resection due to non-availability of glycine and other irrigation fluids which were expensive to import. Distilled sterile water is cheap, available in abundance and safe as irrigation fluid in transurethral resections and though not proven in this study, the intravesical pressure was likely to be less than 40 cmH2O which is the critical pressure above which fluid is significantly absorbed [6–8]. There was no accurate record on the number of capsular perforations but they must have occurred in excess of the 15 recorded cases in this series but without serious consequences as regards TUR syndrome, haemolysis or significant haemorrhage.
Significant peri-operative complications
9 (1.8%) permanent
Total blood loss was low with a post operative transfusion rate of 0.8% which is better than the rate of 8.2% for open prostatectomy [10–12]. This is an advantage in a society with high incidence of HIV/AIDS and other viral transmissible infections.
TURP is associated with a post-operative hypercoagulable state just as in other pelvic surgeries and a deep vein thrombosis (DVT) of 6.8–10%  but most urologists in the locality are apprehensive of using low molecular weight heparin despite this. There were 0.4% patients with DVT in our review ending in fatalities. In spite of this, only physical measures and clotting profile assays were employed to reduce the risk of DVT and pulmonary embolism.
No. of Cases
Channel TURP (adenocarcinoma)
Incidental Bladder neck SCC
The predictors of length of stay are: intrinsic patient factors such as co-morbidities, advances in peri-operative care and surgical techniques and extrinsic hospital factors such as resources, capacity and efficient bed management . The length of stay in our study was governed by deficiencies in all of the above factors. Lack of updated equipments and skilled manpower coupled with patients with multiple co-morbidities was the usual scenario. We were able to show positive correlation between co-morbidities and length of stay in this study (Pearson's correlation 0.233, p ≥ 0.01).
Impotence is reported to occur, in the literature in 11% of cases post-TURP, but only 0.6% was picked up in this study due to incomplete information, which is one of the draw backs of retrospective study.
The cost of treatment is rather high for an average Nigerian as the gross domestic product (GDP) per capita of US$800 is low even within Africa, coupled with poor health allocation from the Budget (2.6%) .
The morbidity and mortality of TURP is expectedly higher than what is obtained internationally, but still lower than what was found following open prostatectomy even in European series. The overall cost of TURP was high for an average Nigerian considering the per capita income of US$800:00 but was worthwhile in view of its inherent minimal trauma, short hospital stay and early recovery. Despite advances in minimally invasive therapy for lower urinary tract symptoms/BPH, TURP is the optimum treatment of choice for BPH in the ageing male population of sub-Saharan Africa, but better facilities and skilled medical staff are needed to make it safer and affordable for the majority of patients in public health institutions.
Professor O.O.Mbonu: for guidance and encouragement in writing this manuscript.
- McConnell JD: Epidemiology, aetiology, pathophysiology, and diagnosis of benign prostatic hyperplasia. Edited by: Walsh PC, Retik AB, Vaughan ED Jr, Wein AJ. 1998, Campbell's Urology, Philadelphia, W.B. Saunders Company, 2: 1429-1449. 7Google Scholar
- Wilson JR, Puri R, Prescott S, Urwin GH: The catheterized patient undergoing transurethral resection of the prostate: a survey of current practice of British Urologists. BJU Int. 2003, 92 (6): 589-591. 10.1046/j.1464-410X.2003.04429.x.View ArticlePubMedGoogle Scholar
- Garraway WM, Collins GN, Lee RJ: High prevalence of benign prostatic hypertrophy in the community. Lancet. 1991, 338: 469-471. 10.1016/0140-6736(91)90543-X.View ArticlePubMedGoogle Scholar
- Stephen JB: The development of human benign prostatic hyperplasia with age. J Urol. 1984, 132: 474-479.Google Scholar
- Serrata V, Morgia G, Fondacaro L, Curto G, Bianco AL, Pirritano D, Melloni D, Orestano F, Motta M, Pavone-Macaluso M, Members Sicilian-Calabrian Society of Urology: Open prostatectomy for benign prostatic enlargement in Southern Europe in the late 1990s: a contemporary series of 1800 interventions. Urol. 2002, 60 (4): 623-627. 10.1016/S0090-4295(02)01860-5.View ArticleGoogle Scholar
- Hulten JO, Tran VT, Petterson G: The control of haemolysis during transurethral resection of the prostate when water is used for irrigation: monitoring absorption by the ethanol method. BJU Int. 2000, 86 (9): 989-992. 10.1046/j.1464-410x.2000.00979.x.View ArticlePubMedGoogle Scholar
- Madsen PP, Naber KG: The importance of pressure in the prostatic fossa and absorption of irrigation fluid during TURP. J Urol. 1973, 109: 446-52.PubMedGoogle Scholar
- Heider H: Frequency and causes of fluid absorption: a comparison of three techniques for resection of the prostate under continuous pressure monitoring. BJU Int. 1999, 83 (6): 619-622. 10.1046/j.1464-410x.1999.00969.x.View ArticleGoogle Scholar
- Ansari MZ, Costello AJ, Ackland MJ, Carson N, McDonald IG: In-Hospital Mortality in Transurethral Resection of the Prostate in Victorian Public Hospitals. Aust NZ J Surg. 2000, 70: 204-208. 10.1046/j.1440-1622.2000.01787.x.View ArticleGoogle Scholar
- Stephenson WP, Chute CG, Guess HA, Schwartz S, Lieber M: Incidence and outcome of surgery for benign prostatic hyperplasia among residents of Rochester, Minesota: 1980–87. Urol. 1991, 38: 32-42. 10.1016/0090-4295(91)80196-E.View ArticlePubMedGoogle Scholar
- Pickard R, Embarton M, Neal DE: The management of men with acute urinary retention. Brit J Urol. 1998, 81: 712-720.View ArticlePubMedGoogle Scholar
- Hammadeh MY, Madaan S, Hines J, Philp T: 5-year outcome of a prospective randomized trial to compare transurethral electrovaporization of the prostate and standard transurethral resection. Urol. 2003, 61 (6): 1165-1171. 10.1016/S0090-4295(03)00109-2.View ArticleGoogle Scholar
- Bell CRW, Murdock PJA, Pasi KJ, Morgan RJ: Thrombotic risk factors associated with transurethral prostatectomy. BJU Int. 1999, 83 (9): 984-989. 10.1046/j.1464-410x.1999.00075.x.View ArticlePubMedGoogle Scholar
- Dawam D, Rafindadi AH, Kalayi GD: Benign prostatic hyperplasia and carcinoma of the prostate in native Africans. BJU Int. 2000, 85 (9): 1074-1077. 10.1046/j.1464-410x.2000.00677.x.View ArticlePubMedGoogle Scholar
- Ansari MZ, MacIntyre CR, Ackland MJ, Chanrary E, Hailey D: Predictors of Length of stay for transurethral prostatectomy in Victoria. Aust NZ J Surg. 2000, 70: 204-208. 10.1046/j.1440-1622.2000.01787.x.View ArticleGoogle Scholar
- Rorberg RI: Nigeria, elections and continuing challenges: The Centre for Preventive Action, Council on Foreign Relations. CSR No. 27. 2007Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/8/18/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.