Reference | Patients/samples | Recurrence rate | Sensitivity(%) | Specificity(%) | NPV (%) | PPV (%) | AUC | Method | Markers |
---|---|---|---|---|---|---|---|---|---|
Roupret et al 2008 [13] | 40/40 | 38% | 80 (microsatellite) 86 (methylation) 85 (combination) | 68 (microsat) 8 (methyl) 86 (combination) | Â | Â | 0.81 (microsat) 0.44 (methyl) | DNA PCR | Microsatellitea vs methylationb |
Van der Aa et al 2009 [14] | 228/815 | 10.3% | 58 | 73 | 94 | 61-77 | NA | DNA PCR | Microsatellite + FGFR3 mutation |
Zuiverloon et al 2010 [15] | 134/463 | 9.7% | 58 | NA | 89 | 25 | NA | DNA PCR | FGFR3 mutationsc |
Reinert et al 2012 [16] | 158/206 | 67.4% | 87-94 | 28-47 | 55-78 | 72-78 | 0.68-0.78 | DNA PCR | Methylation d |
Zuiverloon et al 2012 [17] | NA/94 | 69.1% | 72.3 | 55.2 | NA | NA | NA | DNA PCR | Methylation genes APC_a , TERT_a , TER _b ,EDNRB |
Allory et al 2013 [18] | 194/395 | 44.8% | 19(FGFR3) 42(TERT) 50(FGFR3+TERT) | 73 (TERT) 90(FGFR3) 71(FGFR3+TERT) | NA | NA | NA | DNA PCR | Gene mutations (TERT and FGFR3) |
Abern et al 2014 [19] | 111/111 | 21.6% | 75-79 | 63-71 | 92 | 37-42 | 0.74 (TWIST1) 0.68 (NID2) | DNA PCR | Methylation genes TWIST1, NID2 |
Su et al 2014 [20] | 90/368 | 37.7% | 80 | 97 | NA | NA | 0.95 | DNA PCR | Hyper and hypomethylated genes (SOX1, IRAK3, L1-MET) |
Fantony et al 2015 [21] | 126/126 | 25% | 58-67 | 61-69 | 83-85 | 36-38 | 0.66 (TWIST1) 0.63 (NID2) | DNA PCR | Methylation genes TWIST1, NID2 |
Beukers et al 2016 [22] | NA/2191 | 64% | 57 (LG) 72 (HG) | 59% LG | NA | NA | NA | DNA PCR | FGFR3 mutation, TERT mutation and OTX1 methylation |
Roperch et al 2016 [23] | 158/613 | 45.5% | 94.5 96 (HG) | 75.9 | 98.5 | NA | 0.82 | DNA PCR | FGFR3 mutation +DNA methylation HS3ST2, SLIT2 and SEPTIN9 |
Van der Heijden et al 2018 [24] | NA/458 | 37.7% | 90 | 31 | 82 | 50 | 0.74 | DNA PCR | DNA gene Methylation (CFTR, SALL3, TWIST1) |
Witjes et al 2018 [25] | 353/353 | 13% | 68.2 92.6 (HG) | 88 | 95.1 99.3( HG) | 44.8 | 0.82 | DNA PCR | 15 DNA methylation genes (Epicheck®) |
Springer et al 2018 [26] | 322/322 | 58% | 68 71 (HG) | 80 | NA | NA | NA | DNA PCR | 10 gen mutationse plus detection of aneuploidy (UroSEEK®) |
D’Andrea et al 2019 [27] | 357/357 | 13.7% | 67.3 88.9 (HG) | 88 88(HG) | 94 99 (HG) | 47 30 (HG) | 85.9 | DNA PCR | 15 DNA methylation genes (Epicheck®) |
Batista et al 2019 [28] | 122/122 | 28% | 73.5 | 73.2 | NA | NA | NA | DNA PCR | TERT promoter and FGFR3 mutations (Uromonitor®) |