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Correction to: Skin rash following Administration of Apalutamide in Japanese patients with Advanced Prostate Cancer: an integrated analysis of the phase 3 SPARTAN and TITAN studies and a phase 1 open-label study
BMC Urology volume 20, Article number: 166 (2020)
Correction to: BMC Urol (2020) 20:139 https://doi.org/10.1186/s12894-020-00689-0
In the original publication of this article [1] there were several errors in Table 1 related to the values for Disease status (nmCRPC and mCSPC).
In this correction article the correct and incorrect values are shown.
Table 1Â The correct and incorrect values
Incorrect | Correct | ||||||||
---|---|---|---|---|---|---|---|---|---|
Disease status, n | Disease status, n | ||||||||
nmCRPC | 55 | – | – | 55 | nmCRPC | 34 | – | – | 34 |
mCSPC | – | 51 | – | 51 | mCSPC | – | 28 | – | 28 |
Furthermore, the Time-to-event analyses section has several errors with the decimal values/rounding of numbers, the incorrect and correct information is shown below
Incorrect | Correct |
---|---|
66Â days | 66.0Â days |
45Â days | 45.0Â days |
52Â days | 52.0Â days |
38Â days | 38.0Â days |
82Â days | 82.0Â days |
In the global population of the SPARTAN study, skin rash of any grade resolved for 81% of the patients within 59.5Â days, while the median time to resolution of skin rash of any grade in the TITAN study was 100Â days (Supplementary Table 2) | In the global population of the SPARTAN study, skin rash of any grade resolved for 80.6% of the patients within 59.5Â days, while the median time to resolution of skin rash of any grade in the TITAN study was 100.0Â days (Supplementary Table 2) |
100Â days | 100.0Â days |
35Â days | 35.0Â days |
37Â days | 37.0Â days |
66Â days | 66.0Â days |
Further errors were detected, specifically under the section Management of Rash. This Correction article shows the incorrect and correct sentences. It was highlighted that some of the values on Table 3 were also incorrect. This Correction article shows the correct Table 3. The original article has been updated.
Incorrect:
Oral antihistamine was the most common (25/35 [71.4%]), followed by systemic and topical corticosteroids (18/35 [51.4%] and 15/35 [42.9%], respectively) (Table 3).
Correct:
Topical corticosteroid was the most common (27/35 [77.1%]), followed by oral antihistamine and systemic corticosteroid (18/35 [51.4%] and 3/35 [8.6%], respectively) (Table 3).
In the Discussion section:
Incorrect:
This could be attributed to the more frequent use of oral antihistamines (71.4%) and systemic corticosteroids (51.4%) as supportive medication among Japanese patients when compared with patients in the global studies (combined data from SPARTAN and TITAN: antihistamines, 36.5%; systemic corticosteroids, 18.5%).
Correct:
This could be attributed to the more frequent use of topical corticosteroids (77.1%) and oral antihistamines (51.4%) as supportive medication among Japanese patients when compared with patients in the global studies (combined data from SPARTAN and TITAN: topical corticosteroids, 37.8%; antihistamines, 36.3%.
Reference
Uemura H, Koroki Y, Iwaki Y, et al. Skin rash following Administration of Apalutamide in Japanese patients with Advanced Prostate Cancer: an integrated analysis of the phase 3 SPARTAN and TITAN studies and a phase 1 open-label study. BMC Urol. 2020;20:139. https://doi.org/10.1186/s12894-020-00689-0.
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Uemura, H., Koroki, Y., Iwaki, Y. et al. Correction to: Skin rash following Administration of Apalutamide in Japanese patients with Advanced Prostate Cancer: an integrated analysis of the phase 3 SPARTAN and TITAN studies and a phase 1 open-label study. BMC Urol 20, 166 (2020). https://doi.org/10.1186/s12894-020-00739-7
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DOI: https://doi.org/10.1186/s12894-020-00739-7