Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population

Table 3 Logistic regression analysis of the association between HTR1A and TPH2 gene polymorphisms and risk of LPE.

SNP	Model	Genotype	Control	Case	OR (95% CI)	p-value
rs6295	Co-dominant	C/C	228(63.2%)	59(64.8%)	1.00
		C/G	127(35.2%)	27(29.7%)	3.22(0.95–10.92)	0.060
		G/G	6(1.7%)	5(5.5%)	0.82(0.50–1.36)	0.445
	Dominant	C/C	228(63.2%)	59(64.8%)	1.00
		C/G-G/G	133(36.9%)	32(35.2%)	0.93(0.58–1.50)	0.767
	Recessive	C/C-C/G	355(98.4%)	86(94.5%)	1.00
		G/G	6(1.7%)	5(5.5%)	3.44(1.03–11.54)	0.045 ^*
	Log-additive	---	---	---	1.08(0.70–1.65)	0.731
rs11178996	Codominant	A/A	127(35.1%)	44(48.4%)	1.00
		A/G	158(43.6%)	32(35.2%)	0.56(0.29–1.08)	0.083
		G/G	77(21.2%)	15(16.5%)	0.58(0.35–0.98)	0.040 ^*
	Dominant	A/A	127(35.1%)	44(48.4%)	1.00
		A/G-G/G	235(64.8%)	47(51.7%)	0.58(0.36–0.92)	0.020 ^*
	Recessive	A/A-A/G	285(78.7%)	76(83.6%)	1.00
		G/G	77(21.2%)	15(16.5%)	0.73(0.40–1.34)	0.312
	Log-additive	---	---	---	0.71(0.52–0.98)	0.039 ^*

SNP: Single nucleotide polymorphism; ORs: Odds ratio; 95% CI: 95% confidence intervals;
^* Bold values indicate statistical significance (p < 0.05)

ISSN: 1471-2490