Table 4 Relationship between candidate gene polymorphism and leptin, 5-HT, and folic acid levels in LPE patients

rs11178997

Co-dominant

TT(n = 29)

2.29 ± 2.21

40.06 ± 50.25

40.06 ± 50.25

AT(n = 12)

0.75 ± 0.41

40.30 ± 43.24

40.30 ± 43.24

AA(n = 7)

0.95 ± 0.82

35.61 ± 28.10

35.61 ± 28.10

p-value

0.027 ^*

0.972

0.548

Dominant

TT(n = 29)

2.29 ± 2.21

40.06 ± 50.25

52.91 ± 44.92

AT-AA(n = 19)

0.83 ± 0.58

38.58 ± 37.57

59.16 ± 50.83

p-value

0.007 ^*

0.913

0.657

Recessive

TT-AT(n = 28)

0.95 ± 0.82

35.61 ± 28.10

73.50 ± 57.53

AA(n = 7)

1.84 ± 1.99

40.13 ± 47.77

52.29 ± 44.98

p-value

0.255

0.810

0.274

rs10879346

Co-dominant

TT(n = 16)

1.25 ± 1.29

54.26 ± 57.45

45.20 ± 40.79

TC(n = 25)

1.97 ± 2.26

27.35 ± 27.16

52.40 ± 40.62

CC(n = 7)

1.85 ± 1.52

48.96 ± 59.33

89.33 ± 69.47

p-value

0.488

0.149

0.103

Dominant

TT(n = 16)

1.25 ± 1.29

54.26 ± 57.45

45.20 ± 40.79

TC-CC(n = 32)

1.94 ± 2.10

32.08 ± 36.53

60.47 ± 49.52

p-value

0.232

0.110

0.293

Recessive

TT-TC(n = 41)

1.85 ± 1.52

48.96 ± 59.33

89.33 ± 69.47

CC(n = 7)

1.69 ± 1.96

37.85 ± 43.09

49.59 ± 40.33

p-value

0.834

0.554

0.037 ^*

rs1386492

Co-dominant

CC(n = 17)

1.78 ± 2.20

35.40 ± 41.60

68.93 ± 56.25

TC(n = 22)

1.79 ± 1.79

27.01 ± 29.24

51.42 ± 44.64

TT(n = 9)

1.40 ± 1.64

77.63 ± 64.89

39.49 ± 25.63

p-value

0.864

0.013 ^*

0.277

Dominant

CC(n = 17)

1.78 ± 2.20

35.40 ± 41.60

68.93 ± 56.25

T/C-TT(n = 31)

1.67 ± 1.73

41.71 ± 47.61

47.95 ± 40.00

p-value

0.858

0.649

0.140

Recessive

T/C-C/C(n = 39)

1.78 ± 1.95

30.67 ± 34.91

59.05 ± 50.11

TT(n = 9)

1.40 ± 1.64

77.63 ± 64.89

39.49 ± 25.63

p-value

0.587

0.004 ^*

0.264

rs11178996

Co-dominant

AA(n = 27)

1.96 ± 1.44

43.30 ± 57.21

83.64 ± 66.30

AG(n = 13)

2.62 ± 2.89

33.86 ± 34.20

64.40 ± 49.40

GG(n = 8)

1.20 ± 1.14

41.04 ± 47.47

42.67 ± 34.86

p-value

0.073

0.87

0.065

Dominant

AA(n = 27)

1.20 ± 1.14

41.04 ± 47.47

42.67 ± 34.86

AG-GG(n = 21)

2.37 ± 2.42

37.46 ± 43.24

71.73 ± 55.63

p-value

0.031 ^*

0.789

0.032 ^*

Recessive

AA-AG(n = 40)

1.96 ± 1.44

43.30 ± 57.21

83.64 ± 66.30

GG(n = 8)

1.66 ± 1.97

38.71 ± 43.29

49.73 ± 40.83

p-value

0.687

0.796

0.061