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  • Case report
  • Open Access
  • Open Peer Review

Primary renal squamous cell carcinoma mimicking the renal cyst: a case report and review of the recent literature

BMC Urology201515:69

  • Received: 6 December 2014
  • Accepted: 6 July 2015
  • Published:
Open Peer Review reports



Renal squamous cell carcinoma is a rare neoplasm with poor prognosis. Chronic irritation from nephrolithiasis and/or pyelonephritis is the leading cause.

Case presentation

We described a 51-year-old male patient who was admitted because of left flank pain. Ultrasonography showed a renal cyst containing calculus. However, contrast-enhanced ultrasonography and CT scan revealed an irregular-shaped mass derived from a calculi-containing cyst. Ultrasound guided biopsy confirmed the diagnosis of renal squamous cell carcinoma. The patient refused any further therapeutic management and died six months later.


Our present case emphasizes that the careful diagnostic work-up and use of multiple imaging modalities in cases of unusual renal calculi is quite necessary, since they may carry the risk of co-existing hidden malignancy.


  • Kidney
  • Squamous cell carcinoma


Squamous cell carcinoma (SCC) of the renal pelvis is a rare neoplasm, accounting only 0.5 to 0.8 % of malignant renal tumors [1]. The predisposing factors leading to development of SCC of the renal pelvis include renal calculi, infections, endogenous and exogenous chemicals, vitamin A deficiency, hormonal imbalance and radiotherapy [24]. We reported a case of primary SCC of the renal pelvis, which was unsuspected before biopsy, and the most recent related literatures were reviewed as well.

Case presentation

An otherwise healthy 51-year-old male suffering from persist left flank pain for one week and was referred to the urology department. Physical examination revealed mild left costovertebral angle tenderness but was otherwise normal. Routine diagnostic work-up including chest X-ray and laboratory investigations were all within the normal range, but ultrasonography revealed a renal cyst containing calculus. Further computed tomography (CT) of the kidneys revealed an irregular-shaped homogeneous mass derived from the cyst was found. The mass enveloped the renal pedicle, aorta and inferior vena cava (Fig. 1). The mass was biopsied percutaneously under ultrasonographic guidance. The histological examination revealed squamous cell carcinoma (Fig. 2). Considering that the mass was un-resectable, the patient refused any other treatment. He returned to home hospice and unfortunately died six months later.
Fig 1
Fig 1

CT showed an irregular-shaped homogeneous mass (arrow) derived from the cyst and enveloped the renal pedicle

Fig 2
Fig 2

Biopsy pathology showing a high power view of squamous cell carcinoma (H&E x200)


The kidney is an unusual site for SCC. Renal SCC, most of which is known to arise from collecting system, is a rare clinical entity representing only 0.5 to 0.8 % of malignant renal tumors [1]. It usually occurs in late adulthood and is reported of an equal incidence in men and women [5]. However, according to the recent literatures (Table 1), men bear a higher incidence of renal SCC, probably because of higher incidence of nephrolithiasis in men [2, 620]. Long-standing nephrolithiasis and/or chronic pyelonephritis are the most common causes for renal SCC. Other potential etiology have been described in the literatures, including exogenous and endogenous chemicals (e.g. arsenic), vitamin A deficiency, and prior surgery for renal stones, analgesic abuse, radiotherapy or chronic rejection in a transplant kidney [24]. Chronic irritation can cause squamous metaplasia of the renal collecting system, which may subsequently progress to leukoplakia and neoplasia of the urothelium, resulting in SCC of the renal pelvis. In our case, we speculated that the tumor has arisen in a chronically inflamed hydronephrotic calyx or a calyceal diverticulum with long term irritation by calculi.
Table 1

Characteristics of the reported cases from recent 5 years





Ultrasonographic/radiological feature



Bandyopadhyay et al. [6]



Heaviness and swelling in the left upper abdomen




Imriaco et al. [7]



Left flank abdominal pain

A solid mass within the left side of a horseshoe kidney, with associated large renal stones

Partial left nephrectomy


Mathur et al. [20]



Heaviness and swelling in the left upper abdomen

Non-functional kidney with dilation of renal calyces



Jain et al. [10]



Right flank pain

Staghorn calculi with right renal hydronephrosis






Left lower abdomen pain

Left nephrolithiasis with staghorn calculi and hydronephrosis


Die in hospital because of coronary complication




Left flank pain

Left renal and ureteric calculi with absence of corticomedullary distinction

Nephrectomy + cisplatin-based chemotherapy

Alive at 3 months after surgery




Bilateral flank pain

Right renal calculi with hydronephrosis

Nephrectomy + cisplatin-based chemotherapy

Alive at 5 months after surgery

Paonessa et al. [11]



Vague abdominal pain

Multiple calcified areas within superior pole of the left kidney



Baseskioğlu et al. [13]



Left flank pain and fever

Hydronephrosis, staghorn calculi

Nephrectomy + radiation

Local recurrence, died 3 years later

Verma et al. [12]



Intermittent colicky pain at the right lumbar region

Right pyonephrosis with nephrolithiasis

Pyelithotomy (Palliative) + chemotherapy


Ham et al. [15]



Swelling and pain of right upper abdomen

Severe hydronephrosis with calyceal stones

Nephrectomy + Chemo

Died 7 months later

Bhaijee [14]



Weight loss and severe anemia

Left upper pole renal mass, staghorn calculus and renal vein thrombus


Asymptomatic with no evidence of recurrent or metastatic disease 6 months after surgery

Kalayci et al. [16]



10 kg weight loss

Big, non-functioning right kidney with staghorn calculi and a hypodense mass within the renal parenchyma extending to the upper pole of the right kidney



Palmer et al. [17]



Incidental finding

Large Coarse calculi with dilated renal collecting systems


Died on postoperative day 8

Wu et al. [19]



Intermittent melena, nausea, malaise, and abdominal pain

Heterogeneous renal mass containing a staghorn stone

Exploratory operation + biopsy

Died less than 5 months

Lin et al. [18]




Right renal staghorn calculi

Debulking surgery

Asymptomatic with no evidence of recurrent or metastatic disease 6 months after surgery

Hameed et al. [2]



Chronic backache in the right gluteal region

Complete staghorn calculus with sacral bone metastasis


Died 2 weeks after the 3rd cycle of chemotherapy

aN/A = Not Available

Patients with renal SCC may present with flank or abdominal pain, microscopic or gross hematuria, fever, weight loss or a palpable abdominal mass (Table 1). It could also be the incidental finding on radiographic imaging for other reasons. Establishing the diagnosis of renal SCC by imaging techniques before biopsy or surgery is a clinical dilemma. Conventional ultrasonography is the choice of imaging modality for renal diseases evaluation, but renal SCC lacks specific echoic pattern in ultrasonography. Real-time CEUS was supposed to provide additional information for improving the diagnosis [21]. CT may play a crucial role in diagnosis and staging of the tumor. The radiologic evidences of renal SCC are diverse and may appear as a solid mass with irregular shape, hydronephrosis, calcifications, or as a renal pelvic infiltrative lesion without evidence of a distinct mass. The most helpful feature in CT of renal SCC is presence of enhancing extra-luminal and exophytic mass in some cases, with an intra-luminal component [16]. Lack of specific clinical and radiologic features in renal SCC would result in diagnostic confusion. Thus, the precise histological diagnosis was usually established after nephrectomy. For the un-resectable cases, both endoscopic and percutaneous biopsy could be applied to obtain the specimen. In our case, we chose ultrasound-guided biopsy because the CT scan presented the feature of extensive peritumoral vascular invasion, which indicated that the tumor was un-resectable.

Surgical resection is regarded as the mainstay of treatment for renal SCC [18]. However, the renal SCC is aggressive in nature and concealed. Most cases usually present at an advanced stage-pT3 or higher [16]. Therefore, for the treatment of advanced disease, a multidisciplinary approach comprising of surgical treatment and adjuvant chemoradiotherapy should be applied. Still, the prognosis of renal SCC is generally poor. According to the literatures, the outcome of renal SCC is dismal with a median survival of only several months postoperatively. Holmäng et al. reported that the prognosis of renal SCC is usually poor with a mean survival period of 7 months [5]. The 5-year survival rate is reported less than 10 % [14]. Thus, early diagnosis, monitoring of patients with long-standing nephrolithiasis, and new treatment modalities are urgently needed to improve patients’ outcomes.


For patient with unusual renal calculi, the careful diagnostic work-up with multiple imaging modalities should be applied to exclude the co-existing hidden malignancy.




Squamous cell carcinoma


Contrast-enhanced ultrasonography


Computed tomography


Authors’ Affiliations

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, Zhejiang Province, China
Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
Department of Ultrasonography, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China


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© Jiang et al. 2015

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