Skip to main content
Download PDF

Impact of Endourological procedures with or without double-J stent on sexual function: a systematic review and meta-analysis

BMC Urology volume 20, Article number: 13 (2020) Cite this article

Abstract

Background

Endourological procedures are widely used to treat benign urinary disorders and the double-J stent is routinely used. However, its potential impact on sexual function remains unclear. Therefore, we performed a quantitative systematic review to determine the relationship between endourological procedures with or without double-J stent and post-operative sexual function.

Methods

We conducted a search of PubMed, EMBASE, Web of Science, and Cochrane Library databases up to December 2018 for studies that compared sexual function before and after endourological procedures. The quality of the included studies was evaluated using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I). We performed subgroup analyses to explore heterogeneity. A random effects model was used to combine the results.

Results

Five prospective studies involving 485 sexually active participants were identified. Pooled results showed that, in patients without a double-J stent, the change in sexual function after endourological procedures was not significant in men (mean difference [MD]: − 0.61, 95% confidence interval [CI]: − 1.43 to 0.22, p = 0.148) or women (MD: 0.53, 95% CI: − 0.52 to 1.57, p = 0.322). However, in patients with indwelling double-J stent, sexual function scores significantly declined after the procedure in both men (MD: -4.25, 95% CI: − 6.20 to − 2.30, p < 0.001) and women (MD: -7.17, 95% CI: − 7.88 to − 6.47, p < 0.001).

Conclusions

Our meta-analysis suggests that indwelling double-J stent after endourological procedures could be a crucial factor causing temporary sexual dysfunction post-operatively. Our results may be used to provide evidence-based advice to patients.

Peer Review reports

Background

Urinary stone is a common disease with a prevalence rate varying from 1 to 20% [1]. Endourological procedures (EP), including percutaneous nephrolithotomy (PCNL) and ureteroscopy (URS), are strongly recommended to remove stones according to guidelines [1, 2]. However, these transurethral procedures may have adverse effects on sexual function [3]. In 2003, Joshi et al. firstly found that indwelling double-J stent resulted in sexual problems in 35% of sexually active patients [4, 5]. Increasing concerns were raised about the impact of indwelling double-J stent or EP on sexual function. Sofer et al. utilized a validated questionnaire, the International Index of Erectile Function (IIEF) including five evaluating items, and demonstrated sexual dysfunction after EP regardless of whether double-J stent was applied [3]. It posed the question-is it double-J stent or EP itself that affected sexual function? With accumulated evidence, a pooled analysis is required to address the issue.

Sexual function depends on several functional domains. The International Consultation on Sexual Medicine (ICSM) recommended IIEF and Female Sexual Function Index (FSFI) as sexual dysfunction questionnaire for general population with level of evidence 1A [6]. They assess functions by different sexual feature in both sexes. The IIEF questionnaire for men includes five items: erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction; while the female FSFI questionnaire includes five items: desire, arousal, lubrication, orgasm, satisfaction and pain [7, 8]. The two questionnaires were widely used to evaluate sexual function related to surgeries like abdominal aortic aneurysm surgical repair and bariatric surgery [9, 10]. To address sexual dysfunction after EP, IIEF and FSFI are also the optimal tools.

Sexual activity and fulfillment are essential to maintain emotional well-being and quality of life [11]. Therefore, we conducted the first systematic review to assess the impact of the EP and double-J stent on sexual health, and to provide information for patients counseling when endourological interventions are under consideration. This result is also helpful for urologists to have a comprehensive understanding of the complications of transurethral surgery. Accordingly, optimized surgical strategy could be developed to reduce complications and promote fast recovery after surgery.

Methods

Search strategy

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines [12]. Search was conducted in December 2018 without limitation of starting time of the literature, using PubMed, EMBASE, Web of Science, and Cochrane Library databases. The search keywords were as follows: (endourology OR ureteroscopy OR ureterorenoscopy OR percutaneous nephrolithotomy OR retrograde intrarenal surgery OR stent OR stenting OR stents) AND (sexual function OR sexual dysfunction OR international index of erectile function OR female sexual function index). Furthermore, we scrutinized the reference lists to identify further pertinent studies. The language was restricted to English.

Study selection criteria

Studies meeting the following criteria were included: (1) the study design was prospective; (2) patients were diagnosed with benign urinary disorders including urolithiasis and benign ureteral obstruction; (3) the interventions were endourological procedures (mainly URS and PCNL) with or without ureteral stent; and (4) the outcome was alteration in sexual function assessed by IIEF or FSFI questionnaires. We excluded conference abstracts and studies with missing data. In addition, studies were excluded if sexually inactive patients were recruited.

Quality assessment and data extraction

Two authors (J. Lu and Y. Lu) independently extracted information from the included studies and ranked the study quality based on the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) [13]. Inconsistencies were resolved by discussion with a third reviewer (S. Cao). Extracted data contained study information (first author, publication year, study design), participant characteristics (number of patients, sex, age, type of disease), intervention characteristics (type of endourological procedure, application of stent), outcome characteristics (questionnaires, score of sexual function, evaluation time). The ROBINS-I includes three categories: pre-intervention (confounding, selection of participants), intervention (classification of interventions), and post-intervention (deviations from intended interventions, missing data, measurements of outcomes and selection of the reported results). Each category is assessed as “low risk of bias”, “moderate risk of bias”, “serious risk of bias”, “critical risk of bias”, and “no information”.

Statistical analysis

Combined mean difference with 95% confidence intervals was considered the effect size in this meta-analysis. We compared sexual function scores before and after surgery to assess the alteration. A random effects model was applied to pool the effect sizes. We used the I2 statistic to measure heterogeneity. Values of 0–30% represented minimal heterogeneity, 31–50% represented moderate heterogeneity, and > 50% represented substantial heterogeneity [14]. All statistical analyses were performed using STATA.11.0 (Stata Corp, College Station, Texas, USA). All tests were two-sided with a significance level of 0.05.

Results

Literature search

The initial literature search identified total 568 articles: 95 from PubMed, 188 from Web of Science, 72 from Cochrane Library, and 213 from EMBASE. After removing 78 duplicates, we identified 490 citations. Through screening the titles and abstracts for eligibility, we retrieved 25 articles for full-text assessment. Of these, 20 articles were excluded because 14 articles recruited sexually inactive patients and six articles were conference abstracts. Finally, we included five prospective studies for meta-analysis. The research process is shown in Fig. 1.

Fig. 1
figure1

Flow chart of study search

Full size image

Characteristics and quality of the included studies

Table 1 shows the main characteristics of the five included studies. A total of 485 participants were sexually active. The study publication years ranged from 2007 to 2017. Studies were from three countries (one from Italy [15], one from Egypt [16] and three from Turkey [17,18,19]). All five studies were non-randomized controlled trials. Four studies were ranked as having a “moderate risk of bias” and one study was ranked as having a “serious risk of bias”. Detailed quality assessment by ROBINS-I is available in the Additional file 1. Table 1 lists the characteristics of EP including types of endourology, diameter of endoscope, and description of the stent (diameter, material, and length).

Table 1 The characteristics of included studies
Full size table

Results of meta-analysis

Relationship between sexual function and endourological procedures

Figures 2 and 3 illustrate the results of the pooled mean difference (MD) and 95% confidence interval (CI) of the changes in sexual function in males and females, respectively. Of the five included studies, six groups comprised male patients while the other six groups comprised female patients. The MD of sexual function in men was − 1.7 (95% CI: − 2.94 to − 0.47; p = 0.007), and in women it was − 2.00 (95% CI: − 5.08 to 1.08; p = 0.204).

Fig. 2
figure2

Forest plot of sexual function changes in men. CI, confidence interval

Full size image
Fig. 3
figure3

Forest plot of sexual function changes in women. CI, confidence interval

Full size image

Subgroup analysis

The results of the subgroup analysis are shown in Table 2. We conducted subgroup analysis according to the stent-related state: with stent, without stent, and after stent removal. Stent group showed a significant decrease in sexual function in both sexes: in men, MD = − 4.25 (95% CI: − 6.20 to − 2.30; p < 0.001), and in women, MD = − 7.17 (95% CI: − 7.88 to − 6.47; p < 0.001).

Table 2 Results of subgroup analysis about endourological procedures and sexual function
Full size table

Subdomains of IIEF and FSFI

There are five domains in the IIEF questionnaire: erectile function (EF), intercourse satisfaction (IS), orgasmic function (OF), sexual desire (SD) and overall satisfaction (OS). In our study, two domains of IIEF were slightly impaired after the non-stent procedure: IIEF-EF (MD = − 1.34, 95% CI: − 2.41 to − 0.28; p = 0.014) and IIEF-OF (MD = − 0.58, 95% CI: − 0.77 to − 0.38; p < 0.001).

There are six domains in the FSFI questionnaire: sexual desire (SD), sexual arousal (SA), sexual lubrication (SL), sexual orgasm (SO), sexual satisfaction (SS), sexual pain (SP). In our study, only FSFI-SD was marginally impaired after the non-stent procedure in women (MD = − 0.06, 95% CI: − 0.11 to − 0.01; p = 0.013).

These results are shown in the Additional file 1.

Discussion

Based on current evidence, the indwelling double-J stent negatively correlated with sexual function in all domains. Non-stent procedures had no impact on general sexual function in both sexes even though one or two domains of the administered questionnaires were mildly impaired, including erectile function and orgasmic function in men and sexual desire in women. One study reported that sexual deterioration in women recovered 1 month after stent removal [19]. In another study, the IIEF score remained unchanged on the 10th day after stent removal when compared with the preoperative baseline value [16]. These results suggest that sexual function was impaired after employing a stent but recovered soon following stent removal.

Sexual activity is an important aspect of individual life. The World Health Organization (WHO) describes sexual health as “a state of physical, emotional, mental, and social well-being in relation to sexuality.” [20] Moreover, sexuality is also a way of experiencing pleasure and physical release, facilitating quality of life and longevity [21]. Regular sexual activity varies from 71.3% in old people to 96% in young people. However, the prevalence of erectile dysfunction (ED) ranges from 2.3 to 53.4% according to age [22]. Women appear to be more vulnerable to sexual problems. As many as 40–45% of women have experienced sexual dysfunction during their lifetimes [23]. Unexpected deterioration of sexual function has a significant impact on patients after having undergone certain surgeries. Ureteroscopy preoperatively increases anxiety in patients because of its surgical approach. The passage of rigid material, urethral expansion, and stent placement are new and fear-inducing events for some patients. Patients frequently inquire about the effect these procedures have on sexual function. However, urologists often only provide a simple explanation in accordance with their clinical experience. This systematic literature review provides more accurate evidence for preoperative patient consulting.

Factors that increase the rate of sexual dysfunction after EP are quite complex. EP primarily refers to ureteroscopy, cystoscopy, and percutaneous nephrolithotomy. Upper urinary stones and urinary strictures are considered for EP because malignant diseases such as prostate cancer are often accompanied by nerve injury after radiotherapy or surgery [24]. Surgical injury from ureteroscopy does not directly involve nerves; however, bladder or urethral mucosa may be irritated during the procedure. This depends on the nature of the ureteroscope, its diameter, and rigidity. Two included studies reported detailed information regarding the endoscope. One utilized an 8-Fr semi-rigid ureteroscope, and the other used a 7.5-Fr rigid ureteroscope or cystoscope. No significant change in sexual function was found at the fourth week compared with that at the preoperative baseline. Patients were reported to have had a more comfortable experience after flexible ureteroscopy with decreased pain and anxiety [25]. Nevertheless, in general, sexual dysfunction rarely occurs, even after rigid endoscopy.

The double-J stent is used for drainage and to decrease the incidence of renal colic and ureteral obstruction. Stent-related complications follow the benefits, especially lower urinary tract symptoms (LUTS). A meta-analysis of RCTs compared stent and non-stent procedures to treat ureteral stones [26]. Dysuria, irritation, hematuria, urinary infection, and pain were the top five common complications. The stent group had the highest incidence of flank or voiding pain (31.4% stent vs. 19.7% non-stent), dysuria (51.2% stent vs. 23.0% non-stent), and irritation (45.0% stent vs. 24.2% non-stent). LUTS such as dysuria and irritation are strongly related to sexual dysfunction. A large population-based study reported that odds ratios for ED were 3.0 (storage LUTS vs. no LUTS), 2.6 (voiding LUTS vs. no LUTS) and 4.0 (combined LUTS vs. no LUTS) [27]. The results are similar to those of previous studies. Joshi et al. validated a ureteral stent symptom questionnaire (USSQ) that was widely used to assess stent-associated disturbances [4, 5]. The post-stent LUTS were urgency (57.5%), urge incontinence (18.5%), incomplete emptying (27.5%), and dysuria (18.5%). Two primary complications, LUTS and pain, led to secondary complications described in USSQ: worse general health, impaired work performance, and sexual problems. Apart from LUTS and pain, the evidence showed that the double-J stent also provoked unfavorable mental changes such as anxiety and depression [5, 28]. All stent-associated disturbances (LUTS, pain, mental disorder) may impair sexual health. Included studies in our review utilized specific questionnaires (IIEF and FSFI) to evaluate sexual function. We found a significant decrease of sexual function in stent patients. The parameters of the stent (rigidity, diameter, material, and length) may also affect the degree of complications. Nevertheless, to our knowledge, current studies have not concentrated on whether and how stent technology affects sexual function.

USSQ is utilized to assess the safety of a new stent or medications that can relieve symptoms after placement of a stent. Zhu et al. and Giannarini et al. showed impairment in sexual health in patients compared to that in healthy individuals at four weeks after stent placement [29, 30]. By contrast, some studies showed no significant difference when comparing sexual health at the fourth week after placement with that at the fourth week after removal [30, 31]. A slight improvement of symptoms after stent removal may account for these results. The authors concluded that patients tended to suffer sharp declines in sexual function after stent insertion and sexual function slowly recovered with indwelling time. After the stents were removed, sexual function returned to that at baseline. In addition, medications such as α-blockers and antimuscarinics are effective in relieving stent-related LUTS, pain, and sexual problems [32, 33].

There are several limitations about the systematic review. The primary limitation is the small number of eligible studies and sample sizes. The ROBINS-I tool shows significant bias for the studies. In addition, the sexual function assessment questionnaires were various and the heterogeneity was high in the male groups. Addressing the effect of EP or stent on sexual function still demands well-designed and large sample studies with a standard assessment tool.

Conclusions

Based on current studies, non-stent EP is not likely to influence post-operative sexual function. Employing a double-J stent after surgery may cause temporary sexual dysfunction. This is the first systematic review regarding sexual function change after EP. Studies are lacking to provide definite answer. Further study could focus on stent-related complications including temporary or persistent sexual dysfunction. Better stent design of materials and coatings is encouraged. Moreover, stent use requires strict indications to avoid improper use and to promote fast recovery after surgery.

Availability of data and materials

The datasets in this work is available from the corresponding author.

Abbreviations

CI:

Confidence interval

ED:

Erectile dysfunction

EP:

Endourological procedures

FSFI:

Female Sexual Function Index

IIEF:

International Index of Erectile Function

LUTS:

Lower urinary tract symptoms

MD:

Mean difference

PCNL:

Percutaneous nephrolithotomy

URS:

Ureteroscopy

USSQ:

Ureteral stent symptom questionnaire

References

  1. 1.

    Türk C, Neisius A, Petřík A, Seitz C, Thomas K, Skolarikos A. EAU Guidelines on Urolithiasis 2018. In: European Association of Urology Guidelines 2018 Edition. Volume presented at the EAU Annual Congress Copenhagen 2018, edn. Arnhem: The European Association of Urology Guidelines Office; 2018.

    Google Scholar 

  2. 2.

    Ambani SN, Ghani KR. Stones in 2015: Changes in stone management - suspending belief for evidence. Nat Rev Urol. 2016;13(2):71–2.

    Article  Google Scholar 

  3. 3.

    Sofer M, Yehiely R, Greenstein A, Bar-Yosef Y, Matzkin H, Chen J. Endourological procedures and sexual dysfunction: a prospective multivariate analysis. BJU Int. 2012;109(2):250–3.

    Article  Google Scholar 

  4. 4.

    Joshi HB, Stainthorpe A, MacDonagh RP, Keeley FX Jr, Timoney AG, Barry MJ. Indwelling ureteral stents: evaluation of symptoms, quality of life and utility. J Urol. 2003;169(3):1065–9 discussion 1069.

    CAS  Article  Google Scholar 

  5. 5.

    Joshi HB, Newns N, Stainthorpe A, MacDonagh RP, Keeley FX Jr, Timoney AG. Ureteral stent symptom questionnaire: development and validation of a multidimensional quality of life measure. J Urol. 2003;169(3):1060–4.

    CAS  Article  Google Scholar 

  6. 6.

    Hatzichristou D, Kirana P-S, Banner L, Althof SE, Lonnee-Hoffmann RAM, Dennerstein L, Rosen RC. Diagnosing Sexual Dysfunction in Men and Women: Sexual History Taking and the Role of Symptom Scales and Questionnaires. J Sex Med. 2016;13(8):1166–82.

    Article  Google Scholar 

  7. 7.

    Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D’Agostino R. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–208.

    CAS  Article  Google Scholar 

  8. 8.

    Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822–30.

    CAS  Article  Google Scholar 

  9. 9.

    Regnier P, Lareyre F, Hassen-Khodja R, Durand M, Touma J, Raffort J. Sexual Dysfunction After Abdominal Aortic Aneurysm Surgical Repair: Current Knowledge and Future Directions. Eur J Vasc Endovasc Surg. 2018;55(2):267–80.

    Article  Google Scholar 

  10. 10.

    Gao Z, Liang Y, Deng W, Qiu P, Li M, Zhou Z. Impact of Bariatric Surgery on Female Sexual Function in Obese Patients: a Meta-Analysis. Obes Surg. 2019;30:352–64.

    Article  Google Scholar 

  11. 11.

    Lee DM, Nazroo J, O’Connor DB, Blake M, Pendleton N. Sexual Health and Well-being Among Older Men and Women in England: Findings from the English Longitudinal Study of Ageing. Arch Sex Behav. 2016;45(1):133–44.

    Article  Google Scholar 

  12. 12.

    Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Group P-P. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.

    Article  Google Scholar 

  13. 13.

    Sterne JA, Hernan MA, Reeves BC, Savovic J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.

    Article  Google Scholar 

  14. 14.

    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.

    Article  Google Scholar 

  15. 15.

    Sighinolfi MC, Micali S, De Stefani S, Mofferdin A, Grande A, Giacometti M, Ferrari N, Rivalta M, Bianchi G. Indwelling ureteral stents and sexual health: A prospective, multivariate analysis. J Urol. 2007;178(1):229–31.

    CAS  Article  Google Scholar 

  16. 16.

    Mosharafa A, Abd El Hamid M, Tawfik M, Abd El Rzzak O. Effect of endourological procedures on erectile function: a prospective cohort study. Int Urol Nephrol. 2016;48(7):1055–9.

    Article  Google Scholar 

  17. 17.

    Eryildirim B, Tuncer M, Sahin C, Yucetas U, Sarica K. Evaluation of sexual function in patients submitted to ureteroscopic procedures. Int Braz J Urol. 2015;41(4):791–5.

    Article  Google Scholar 

  18. 18.

    Akdeniz E, Bolat MS. Ureterorenoscopy with Stenting and Its Effect on Female Sexual Function. J Urol. 2017;14(3):3059–63.

    Google Scholar 

  19. 19.

    Eryildirim B, Tuncer M, Kuyumcuoglu U, Faydaci G, Tarhan F, Ozgul A. Do ureteral catheterisation procedures affect sexual functions? A controlled prospective study. Andrologia. 2012;44(Suppl 1):419–23.

    Article  Google Scholar 

  20. 20.

    World Health Organization, Gender and human rights. https://wwwwhoint/reproductivehealth/topics/gender_rights/sexual_health/en/ Accessed 18 Mar 2015.

  21. 21.

    Sadovsky R, Nusbaum M. Sexual health inquiry and support is a primary care priority. J Sex Med. 2006;3(1):3–11.

    Article  Google Scholar 

  22. 22.

    Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U. Epidemiology of erectile dysfunction: results of the 'Cologne Male Survey'. Int J Impot Res. 2000;12(6):305–11.

    CAS  Article  Google Scholar 

  23. 23.

    Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED Jr, Rellini AH, Segraves T. Definitions/epidemiology/risk factors for sexual dysfunction. J Sex Med. 2010;7(4 Pt 2):1598–607.

    Article  Google Scholar 

  24. 24.

    Barocas DA, Alvarez J, Resnick MJ, Koyama T, Hoffman KE, Tyson MD, Conwill R, McCollum D, Cooperberg MR, Goodman M, et al. Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years. JAMA. 2017;317(11):1126–40.

    Article  Google Scholar 

  25. 25.

    Krajewski W, Koscielska-Kasprzak K, Rymaszewska J, Zdrojowy R. How different cystoscopy methods influence patient sexual satisfaction, anxiety, and depression levels: a randomized prospective trial. Qual Life Res. 2017;26(3):625–34.

    Article  Google Scholar 

  26. 26.

    Wang H, Man L, Li G, Huang G, Liu N, Wang J. Meta-Analysis of Stenting versus Non-Stenting for the Treatment of Ureteral Stones. PloS one. 2017;12(1):e0167670.

    Article  Google Scholar 

  27. 27.

    Morant S, Bloomfield G, Vats V, Chapple C. Increased sexual dysfunction in men with storage and voiding lower urinary tract symptoms. J Sex Med. 2009;6(4):1103–10.

    Article  Google Scholar 

  28. 28.

    Bolat MS, Akdeniz E, Asci R, Erdemir F, Cinar O, Tomak L: Ureterorenoscopy with stenting and its effect on male sexual function: A controlled randomised prospective study. Andrologia 2017, 49(9).

    Article  Google Scholar 

  29. 29.

    Zhu C, Qu J, Yang L, Feng X: The Chinese Linguistic Validation of the Ureteral Stent Symptom Questionnaire. Urologia internationalis 2018:1-5.

  30. 30.

    Giannarini G, Keeley FX Jr, Valent F, Manassero F, Mogorovich A, Autorino R, Selli C. Predictors of morbidity in patients with indwelling ureteric stents: results of a prospective study using the validated Ureteric Stent Symptoms Questionnaire. BJU Int. 2011;107(4):648–54.

    Article  Google Scholar 

  31. 31.

    Tanidir Y, Mangir N, Sahan A, Sulukaya M. Turkish version of the Ureteral Stent Symptoms Questionnaire: linguistic and psychometric validation. World J Urol. 2017;35(7):1149–54.

    Article  Google Scholar 

  32. 32.

    Zhou L, Cai X, Li H, Wang KJ. Effects of alpha-Blockers, Antimuscarinics, or Combination Therapy in Relieving Ureteral Stent-Related Symptoms: A Meta-Analysis. J Endourol. 2015;29(6):650–6.

    Article  Google Scholar 

  33. 33.

    Dellis AE, Papatsoris AG, Keeley FX Jr, Bamias A, Deliveliotis C, Skolarikos AA. Tamsulosin, Solifenacin, and Their Combination for the Treatment of Stent-Related Symptoms: A Randomized Controlled Study. J Endourol. 2017;31(1):100–9.

    Article  Google Scholar 

Download references

Acknowledgments

Not applicable.

Funding

This work was supported by grants from the National Natural Science Foundation of China (NSFC, 71603091).

Author information

Author notes

  1. Co-first authors: Junlin Lu and Yinghong Lu contributed equally to this work

Affiliations

  1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Junlin Lu, Yang Xun & Shaogang Wang

  2. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Yinghong Lu, Fan Chen & Shiyi Cao

Authors
  1. Junlin Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yinghong Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yang Xun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shaogang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shiyi Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

JL: conception and design, project development, article research, article review, pictures production, manuscript writing and revising; YL: design, project development, article review, data extract, statistical analysis and manuscript revising; YX: project development and manuscript revising; FC: project development and manuscript revising; SW: project development, supervision and manuscript revising; SC: project development, supervision and manuscript revising. All authors have read and approved the final manuscript.

Corresponding authors

Correspondence to Shaogang Wang or Shiyi Cao.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Additional file 1.

Supplementary materials are available.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lu, J., Lu, Y., Xun, Y. et al. Impact of Endourological procedures with or without double-J stent on sexual function: a systematic review and meta-analysis. BMC Urol 20, 13 (2020). https://doi.org/10.1186/s12894-020-0582-1

Download citation

Keywords

  • Sexual dysfunction
  • Double-J stent
  • Ureteroscopy
  • Urolithiasis
  • Endourological procedures

BMC Urology

ISSN: 1471-2490

Contact us